Heart Health: Long-Term Melatonin Use Linked to Cardiovascular Risk

New research indicates that individuals with insomnia who take melatonin supplements for over a year face a higher chance of developing heart failure compared to those who do not use the sleep aid. The study revealed that long-term melatonin use is associated with an increased likelihood of being diagnosed with heart failure, needing hospitalization for it, or dying from any cause.

This research is scheduled to be presented at the American Heart Association’s Scientific Sessions 2025 in New Orleans. However, the study remains preliminary and has not yet undergone peer review.

Research Findings and Limitations

The researchers emphasize that their findings do not confirm a direct cause-and-effect link between melatonin supplementation and heart failure. Still, the results highlight potential safety concerns regarding extended use of melatonin and suggest the need for more detailed investigations into its cardiovascular effects.

Concerns About Supplement Regulation

Many melatonin products are available over-the-counter without prescriptions and lack regulatory oversight. This allows individuals to use melatonin without medical supervision, raising additional safety questions.

“Melatonin supplements may not be as harmless as commonly assumed.”

Author’s Summary

Long-term use of melatonin supplements may increase the risk of heart failure, underscoring the importance of further research and cautious use under medical guidance.

Healthline — 2025-11-05