Antibody Therapy Breaks Immune Evasion in Pancreatic Cancer
Pancreatic cancer is notoriously hard to treat and often resists the most advanced immunotherapies.
Northwestern Medicine scientists have uncovered a novel explanation for that resistance: Pancreatic tumors use a sugar-based disguise to hide from the immune system.
The scientists also created an antibody therapy that blocks the sugar-mediated “don’t-attack” signal.
For the first time, the team identified how this sugar trick works and showed that blocking it with a monoclonal antibody reawakens immune cells to attack cancer cells in preclinical mouse models.
The team identified how this sugar trick works and showed that blocking it with a monoclonal antibody reawakens immune cells to attack cancer cells.
Author's summary: Antibody therapy helps fight pancreatic cancer.
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