Early TNF Inhibitor Use Improves Outcomes in Nonsystemic JIA

Early TNF Inhibitor Use Improves Outcomes in Nonsystemic JIA

Early initiation of TNF inhibitors among children with non-sJIA led to significant and sustained improvements in disease activity.

Researchers found that early initiation of tumor necrosis factor (TNF) inhibitor therapy among children diagnosed with nonsystemic juvenile idiopathic arthritis (non-sJIA) at 2 years or less leads to significant and sustained improvements in disease activity.

Study results, presented at the American College of Rheumatology (ACR) Convergence 2025, used data from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry from 2015 to 2023.

Authors aimed to describe demographic and disease characteristics of children! diagnosed with non-sJIA from 0 to 23 months.

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Summary: Early TNF inhibitors improve non-sJIA outcomes.

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Rheumatology Advisor Rheumatology Advisor — 2025-10-27

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