Amphista Therapeutics, a leader in next-generation targeted protein degradation (TPD), has published a study in Nature Communications detailing the successful degradation of the key cancer target BRD9 via a novel mechanism using DCAF16 E3 ligase.
The company's proprietary Targeted Glues are rationally designed medicines that integrate the favorable performance characteristics of earlier generation PROTACs and conventional molecular glues, while addressing key limitations.
"The deep expertise of our scientists led to the successful integration of the favorable performance characteristics of earlier generation PROTACs and conventional molecular glues but with key limitations designed-out." - Louise Modis, PhD, Chief Scientific Officer at Amphista Therapeutics
Author's summary: Amphista Therapeutics publishes breakthrough cancer research.