Rashid Gedel, 25, and Samuel Dodsworth, 43, have been charged with murder and appeared before Leeds Magistrates' Court.
Ian Watkins, the disgraced frontman of Lostprophets, was fatally injured in an incident at Wakefield Prison on Saturday.
Watkins was jailed in 2013 for child sex offences, including the attempted rape of a baby.
No comment from the defendants is available at this time.
Author's summary: Two men charged with murder of paedophile singer.