Long-term use of melatonin supplements to support sleep may have negative health effects

Long-term Use of Melatonin Supplements May Carry Health Risks

A recent review analyzed five years of health records from more than 130,000 adults with insomnia who had taken melatonin for at least one year. Researchers found these individuals faced a higher likelihood of developing heart failure, being hospitalized for the condition, and experiencing death from any cause.

The findings are part of a preliminary study that will be presented at the American Heart Association’s Scientific Sessions 2025, taking place November 7–10 in New Orleans. The event serves as a global platform for sharing the latest scientific discoveries and advancements in cardiovascular health.

Background on Melatonin

Melatonin is a hormone naturally secreted by the pineal gland that regulates the body’s sleep-wake rhythm. Its levels rise at night and decline during the day. Synthetic melatonin, which mimics the body’s own hormone, is commonly used to help relieve insomnia and jet lag.

Availability and Regulation

Melatonin supplements are easily available without a prescription in many countries, including the United States. However, over-the-counter supplements are not subject to strict government quality control, so their strength and purity can vary between brands.

“Long-term use of melatonin supplements, often used to promote sleep and address insomnia, was associated with a higher risk of heart failure diagnosis, heart failure hospitalization, and death from any cause in chronic insomnia.”
Research Context

Author’s Summary: Long-term use of melatonin may disrupt heart health, signaling that even natural sleep aids can pose serious risks when used chronically.

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www.heart.org www.heart.org — 2025-11-04

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