Think melatonin is safe? New research reveals a hidden heart risk

Long-Term Melatonin Use May Pose Heart Risks

New research suggests that chronic use of melatonin for sleep issues could unexpectedly harm heart health. People who use melatonin regularly have nearly double the risk of death and are 3.5 times more likely to be hospitalized due to heart failure.

Study Highlights Increased Heart Failure Risk

A preliminary study shared at the American Heart Association's Scientific Sessions 2025 revealed that adults with chronic insomnia taking melatonin for a year or more were at greater risk of developing heart failure, being hospitalized for it, and dying from any cause compared to non-users.

The results are set to be discussed in detail at the AHA annual meeting held from November 7 to 10 in New Orleans, a key event for cardiovascular research and clinical updates.

What is Melatonin?

Melatonin is a hormone produced by the pineal gland that controls the sleep-wake cycle, increasing in the dark and decreasing with daylight. Synthetic melatonin supplements mirror the natural hormone and are commonly used to treat insomnia and jet lag.

In many countries, including the U.S., melatonin is available over the counter. However, because U.S. supplements are not tightly regulated, product purity and dosage can vary significantly.

"Adults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement."
Expert Caution

Though melatonin is generally seen as safe, health experts now advise caution with long-term use due to these emerging risks.

Author's summary: Recent findings link extended melatonin use to a higher risk of heart failure and death, urging careful consideration before chronic supplementation.

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ScienceDaily ScienceDaily — 2025-11-04

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